pam 3 csk 4 (InvivoGen)

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InvivoGen pam 3 csk 4

Six-weeks-old C57BL/6 male mice were mock-transduced or transduced with 10 11 ⍰vge of AAV-HBV 1.3 mer genotype D/serotype ayw for 31 days to allow establishment of chronic infection. At day-35, treatment cycles were started, after mice were evenly grouped according to viremia and HBsAg antigenemia. Mice (n⍰= ⍰7/group) were injected, at indicated days with vehicle (PBS), free/non vectorized <t>Pam</t> <t>3</t> <t>CSK</t> <t>4</t> at 100 μg/injection, NP-Pam 3 CSK 4 at 5 μg/shot, or NP-Pam 3 CSK 4 at 20 μg/shot. 3TC was administrated continously at approximately 100 mg/kg/day (in drinking water) between days-35 and 64 and days-79 and 90. Blood/serum was collected at indicated times (blood drop symbol). Mice were euthanized at 90 days post-transduction. The different readouts and used techniques for exploitation of blood and liver samples are indicated.

Pam 3 Csk 4, supplied by InvivoGen, used in various techniques. Bioz Stars score: 99/100, based on 3906 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pam+3+csk/Pam3CSK4/bio_rxiv__64898__2026__05__27__728102-37-1-5
Average 99 stars, based on 3906 article reviews

pam 3 csk 4 - by Bioz Stars, 2026-09

99/100 stars

Images

1) Product Images from "Preclinical antiviral study of a liver-targeted TLR1/2 agonist in an immune-competent mouse model of HBV infection"

Article Title: Preclinical antiviral study of a liver-targeted TLR1/2 agonist in an immune-competent mouse model of HBV infection

Journal: bioRxiv

doi: 10.64898/2026.05.27.728102

Figure Legend Snippet: Six-weeks-old C57BL/6 male mice were mock-transduced or transduced with 10 11 ⍰vge of AAV-HBV 1.3 mer genotype D/serotype ayw for 31 days to allow establishment of chronic infection. At day-35, treatment cycles were started, after mice were evenly grouped according to viremia and HBsAg antigenemia. Mice (n⍰= ⍰7/group) were injected, at indicated days with vehicle (PBS), free/non vectorized Pam 3 CSK 4 at 100 μg/injection, NP-Pam 3 CSK 4 at 5 μg/shot, or NP-Pam 3 CSK 4 at 20 μg/shot. 3TC was administrated continously at approximately 100 mg/kg/day (in drinking water) between days-35 and 64 and days-79 and 90. Blood/serum was collected at indicated times (blood drop symbol). Mice were euthanized at 90 days post-transduction. The different readouts and used techniques for exploitation of blood and liver samples are indicated.

Techniques Used: Transduction, Infection, Injection

other:

Article Title: A20 restriction of nitric oxide production restores macrophage bioenergetic balance
Article Snippet: The doses of ligands used were as follows: lipopolysaccharide 100 ng/ml; poly(I:C) HMW 20 μg/ml; Pam 3 CSK 4 1 μg/ml; CpG-A 2 μM; CpG-B 250 nM, Gardiquimod 1 μg/ml; PolyU (complexed with lipofectamine) 0.5 μg/ml and flagellin (from S. typhimurium ) 2 μg/ml (Invivogen).

Article Title: Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei
Article Snippet: For the Sunpasitthiprasong Hospital study the stimulants analyzed were B . pseudomallei K96243 LPS 10 ng/ml, B . pseudomallei V688 LPS 10 ng/ml, B . pseudomallei 558 LPS 10 ng/ml, S . Typhimurium strain SL1344 deficient in flgM flagellin 500 ng/ml, Pam 3 CSK 4 100 ng/ml (Invivogen, San Diego, CA), and E . coli 0111:B4 LPS 10 ng/ml (List Biological Laboratories, Campbell, CA).

Article Title: Gamma Interferon and Interleukin-1 Receptor 1 Regulate Neutrophil Recruitment to the Corneal Stroma in a Murine Model of Onchocerca volvulus Keratitis
Article Snippet: Cells were allowed to rest overnight before being stimulated with 5 ng of rIFN-γ (Peprotech)/ml; 0.4, 2, or 10 μg of OvAg/ml; or 10, 100, or 1,000 ng of Pam 3 CSK (Invivogen)/ml.

Article Title: XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection
Article Snippet: Where indicated, cells were treated for 30 min with TLR ligands as follows: MDP 10 μg/ml (Bachem #4009623), Pam 3 CSK 4 2 μg/ml (Invivogen #tlrl-pms), poly (I:C) 10 μg/ml, LPS 10 ng/ml (Sigma #L6143), flagellin 10 ng/ml (Invivogen #tlrl-flic), imiquimod 5 μg/ml (Invivogen #tlrl-imq), CpG DNA 1 μg/ml (IDT CpG F [ 5′-TCCATGACGTTCCTGACGTT ], CpG R [ 5′-AACGTCAGGAACGTCATGGA ]).

Concentration Assay:

Article Title: Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity
Article Snippet: .. Adjuvants were obtained from Invivogen (Vaccigrade) and used at the following concentration: Alhydrogel ® 2%, Pam 3 CSK 4 2.5 μg/ml, PolyI:C 5 μg/ml, LPS 1 μg/ml, R848 2.5 μg/ml, and ODN2006 5 μg/ml. ..

Incubation:

Article Title: Filaria/Wolbachia activation of dendritic cells and development of Th1-associated responses is dependent on Toll-like receptor 2 in a mouse model of ocular onchocerciasis (river blindness).
Article Snippet: Toll-like receptors (TLRs) regulate dendritic cell function and activate signals that mediate the nature of the adaptive immune response.. The current study examined the role of TLRs in dendritic cell activation and in regulating T cell and antibody responses to antigens from the filarial parasites Onchocerca volvulus and Brugia malayi , which cause river blindness and lymphatic filariasis, respectively.. Bonemarrow-derived CD11c + cells from C57BL/6 and TLR4 –/– mice produced high levels of IL-6 and RANTES, and showed elevated surface CD40 expression, whereas CD11c + cells from myeloid differentiation factor 88 –/– (MyD88 –/– ), TLR2 –/– and TLR2/4 –/– mice were not activated.

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